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MLL2 Antibody (N-Term)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC, E |
|---|---|
| Primary Accession | O14686 |
| Other Accession | NP_003473.3, 8085 |
| Reactivity | Human |
| Host | Goat |
| Clonality | Polyclonal |
| Concentration | 0.5 mg/ml |
| Isotype | IgG |
| Calculated MW | 593389 Da |
| Gene ID | 8085 |
|---|---|
| Other Names | Histone-lysine N-methyltransferase 2D, Lysine N-methyltransferase 2D, 2.1.1.43, ALL1-related protein, Myeloid/lymphoid or mixed-lineage leukemia protein 2, KMT2D, ALR, MLL2, MLL4 |
| Dilution | IHC~~1:100~500 E~~N/A |
| Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | MLL2 Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | KMT2D |
|---|---|
| Synonyms | ALR, MLL2, MLL4 |
| Function | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:17500065, PubMed:25561738). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription (PubMed:16603732). |
| Cellular Location | Nucleus. |
| Tissue Location | Expressed in most adult tissues, including a variety of hematoipoietic cells, with the exception of the liver |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The immunizing peptide was designed from NP_003473.1. Since then the sequence has changed in the databases and currently differs at two locations in NP_003473.3.
References
Structure and expression pattern of human ALR, a novel gene with strong homology to ALL-1 involved in acute leukemia and to Drosophila trithorax. Prasad R, Zhadanov AB, Sedkov Y, Bullrich F, Druck T, Rallapalli R, Yano T, Alder H, Croce CM, Huebner K, Mazo A, Canaani E. Oncogene. 1997 Jul 31;15(5):549-60. PMID: 9247308
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